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Wikipedia - Valrubicin

Valrubicin
Systematic (IUPAC) name
2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate
Identifiers
CAS number 56124-62-0
ATC code L01DB09
PubChem CID 41744
DrugBank APRD00662
Chemical data
Formula C34H36F3NO13 
Mol. mass 723.644 g/mol
Pharmacokinetic data
Bioavailability Negligible
Protein binding >99%
Metabolism Negligible
Excretion In urine
Therapeutic considerations
Pregnancy cat. C(US)
Legal status ? Prescription only
Routes Intravesical

Valrubicin (N-trifluoroacetyladriamycin-14-valerate, trade name Valstar) is a chemotherapy drug used to treat bladder cancer. Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder.

It was originally launched as Valstar in the U.S. in 1999 for intravesical therapy of Bacille Calmette-Guérin (BCG)-refractory carcinoma in situ of the urinary bladder in patients in whom cystectomy would be associated with unacceptable morbidity or mortality; however, it was voluntarily withdrawn in 2002 due to manufacturing issues.[1] Valstar was relaunched on September 3, 2009.[2]

[edit] Dosage

800 mg weekly for 6 weeks

[edit] Side effects

[edit] References

  1. ^ "Manufacturing Issues Remain for Indevus' Valstar", U.S. Food and Drug Administration News. The MQN Weekly Bulletin, Jan. 11, 2008
  2. ^ "Endo Pharmaceuticals launches VALSTAR for treating recurrent carcinoma in situ bladder tumors". Press release. 2009-09-03. http://www.news-medical.net/news/20090903/Endo-Pharmaceuticals-launches-VALSTAR-for-treating-recurrent-carcinoma-in-situ-bladder-tumors.aspx. Retrieved 2009-11-26. 
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Retrieved from "http://en.wikipedia.org/wiki/Valrubicin"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Valrubicin".

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